The tumor suppressor kinases LATS1 and LATS2 (LATS1/2) regulate not only organ size through the Hippo signaling pathway. but also cell-cycle checkpoints and apoptosis via other signaling cascades. We previously reported that LATS1/2 localize to the mitotic apparatus. where they are involved in the phosphorylation and activation of the mitotic kinase Aurora-B; however. https://www.lolasalinas.com/